Malignant neoplasm of urinary bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Survival analysis showed that PCMT1 protein high-expression was an independent unfavorable prognostic factor for bladder cancer patients.
|
29517839 |
2018 |
Bladder Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Survival analysis showed that PCMT1 protein high-expression was an independent unfavorable prognostic factor for bladder cancer patients.
|
29517839 |
2018 |
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
PCMT1 protein expression was obviously correlated with clinical stage, muscularis invasion, lymph node metastasis, and distant metastasis.
|
29517839 |
2018 |
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We previously reported that PIMT was downregulated at both gene and protein levels by DA-induced oxidative stresses in SH-SY5Y neuroblastoma cells.
|
25800307 |
2015 |
Parkinson Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This suggests that ROS generated from cytosolic dopamine could reduce both the PCMT1 gene promoter activity and the PIMT protein level thus decreasing its capacity to repair proteins involved in apoptosis and could contribute to neuronal cell death observed in PD.
|
24631677 |
2014 |
Schizophrenia
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia.
|
19110265 |
2009 |
Carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Survival analysis showed that PCMT1 protein high-expression was an independent unfavorable prognostic factor for bladder cancer patients.
|
29517839 |
2018 |
Central neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We previously reported that PIMT was downregulated at both gene and protein levels by DA-induced oxidative stresses in SH-SY5Y neuroblastoma cells.
|
25800307 |
2015 |
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
PCMT1 protein expression was obviously correlated with clinical stage, muscularis invasion, lymph node metastasis, and distant metastasis.
|
29517839 |
2018 |
Childhood Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We previously reported that PIMT was downregulated at both gene and protein levels by DA-induced oxidative stresses in SH-SY5Y neuroblastoma cells.
|
25800307 |
2015 |
Spina Bifida
|
0.320 |
Biomarker
|
disease |
CTD_human |
Our results showed that the Ile120Val polymorphism of PCMT1 gene is a genetic modifier for the risk of spina bifida.
|
16256389 |
2006 |
Status Dysraphicus
|
0.300 |
Biomarker
|
disease |
CTD_human |
A known functional polymorphism (Ile120Val) of the human PCMT1 gene and risk of spina bifida.
|
16256389 |
2006 |
Rachischisis
|
0.300 |
Biomarker
|
disease |
CTD_human |
A known functional polymorphism (Ile120Val) of the human PCMT1 gene and risk of spina bifida.
|
16256389 |
2006 |
Glioma
|
0.200 |
Biomarker
|
disease |
RGD |
Expression and activity of l-isoaspartyl methyltransferase decrease in stage progression of human astrocytic tumors.
|
15857672 |
2005 |
Malignant Glioma
|
0.200 |
Biomarker
|
disease |
RGD |
Expression and activity of l-isoaspartyl methyltransferase decrease in stage progression of human astrocytic tumors.
|
15857672 |
2005 |
Epilepsy
|
0.030 |
Biomarker
|
disease |
BEFREE |
Pcmt1 knock-out mice exhibit a profound neuropathology and die 30-60 days postnatal from an epileptic seizure.
|
28100787 |
2017 |
Epilepsy
|
0.030 |
Biomarker
|
disease |
BEFREE |
Pcmt1 knockout mice exhibit a profound neuropathology and die 30-60 days postnatal from an epileptic seizure.
|
29856810 |
2018 |
Epileptic Seizures
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Pcmt1 knockout mice exhibit a profound neuropathology and die 30-60 days postnatal from an epileptic seizure.
|
29856810 |
2018 |
Epileptic Seizures
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Pcmt1 knock-out mice exhibit a profound neuropathology and die 30-60 days postnatal from an epileptic seizure.
|
28100787 |
2017 |
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The role of protein l-isoaspartate (d-aspartate) O-methyltransferase (PCMT1) in human cancer was generally cognized.
|
29517839 |
2018 |
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results support a role for post-translational modifications and PIMT in the development of type 1 diabetes in the diabetes-prone BB rat, and perhaps also in humans.
|
17216280 |
2007 |
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
The results support a role for post-translational modifications and PIMT in the development of type 1 diabetes in the diabetes-prone BB rat, and perhaps also in humans.
|
17216280 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to assess the role of PIMT in the development of type 1 diabetes.
|
17216280 |
2007 |
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, cumulative evidence suggests that PIMT functions in cardiac energy metabolism by interacting with nuclear receptor coactivators and this property could be useful in the management of heart failure.
|
29772707 |
2018 |
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, cumulative evidence suggests that PIMT functions in cardiac energy metabolism by interacting with nuclear receptor coactivators and this property could be useful in the management of heart failure.
|
29772707 |
2018 |